MDH-PSAT Coupling Assay

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酶底物特异性检测

丝氨酸代谢

数据链接：

https://dataverse.harvard.edu/citation?persistentId=doi:10.7910/DVN/27638 数据链接链接失效反馈

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资源简介：

Assay used to test substrate specificity of ChPSAT, a putative phosphoserine AT from c. Hutchinsonii.

创建时间：

2014-10-19

Table 5_Modulating the serine metabolism in human differentiated astrocytes: an integrated multi omics approach.xlsx

星形胶质细胞代谢

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IntroductionAstrocytes are the major source of L-serine (L-Ser) in the brain: the glycolytic intermediate D-3-phosphoglycerate is converted into L-Ser through the phosphorylated pathway (PP) made up o

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Gene Regulation by ATF3 in response to serine deprivation

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The goal of this study is to identify genes that are regulated by activiating transcription factor (ATF3) in the cellular response to serine deprivation. Serine biosynthesis is crucial for cancer cell

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Expression data from parental MDA-MB-231 cells and MDA-MB-231(SA) variant

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Since bone metastatic breast cancer is an incurable disease, causing significant morbidity and mortality, understanding of the underlying molecular mechanisms would be highly valuable. Here, we descri

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Exogenous and Endogenous Sources of Serine Contribute to Colon Cancer Metabolism and Growth

结肠癌代谢

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Serine is a non-essential amino acid that is generated by the sequential actions of phosphoglycerate dehydrogenase (PHGDH), phosphoserine aminotransferase (PSAT1) and phosphoserine phosphatase (PSPH).

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Decreased serine biosynthesis identifies a subgroup of platinum resistant ovarian cancers and novel actionable metabolic vulnerabilities

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Resistance to platinum-based chemotherapy represents a major clinical challenge for many tumors, particularly epithelial ovarian cancer. After initial response, patients often experience several respo

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MDH-PSAT Coupling Assay

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