O'Donovan2022 - the Mixed Meal Model

The Mixed Meal Model is a physiology based mathematical model describing the post-meal interplay between glucose, insulin, triglycerides and non-esterified fatty acids (NEFA).The Mixed Meal Model can be fit to meal response data by estimating nine model parameters from measured plasma glucose, insulin, triglyceride, and NEFA trajectories. These estimated model parameters have been shown to capture features of insulin resistance, beta-cell functionality, and liver fat accumulation from the meal response data.