Clinical features of subjects with type 2 diabetes (T2D) in each quartile of the unweighted (upper panel) and weighted (lower panel) combined genetic score (CGS), respectively.

Data are shown as N, %, mean±SD or median (minimum to maximum). Between-group comparisons of clinical characteristics were performed by χ2 test or logistic regression analysis for categorical variables, and one-way ANOVA or linear regression analysis for continuous variables, as appropriate. Analysis for age at diagnosis was adjusted for sex, body mass index (BMI) and HbA1c. Analysis for BMI and central obesity were adjusted for sex and age. Analysis for waist circumference (stratified by sex) was adjusted for age. Analysis for HbA1c was adjusted for sex, age and BMI. Analysis for insulin therapy was adjusted for sex, age, smoking status, HbA1c, baseline eGFR and drug usages (lipid lowering, blood pressure anti-hypertensive, ACE inhibitor and oral glucose lowering). Q1, quartile 1; Q2, quartile 2; Q3, quartile 3; Q4, quartile 4; T2D, type 2 diabetes.