Unified Approach for the Total Synthesis of bis-THF C15 Acetogenins: a Chloroenyne from Laurencia Majuscula, Laurendecumenyne B and Laurefurenynes A/B
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A highly diastereoselective total synthesis of several <em>bis</em>-THF C<sub>15</sub> acetogenin class of natural products: chloroenyne from <em>Laurencia</em> <em>Majuscula</em>, laurendecumenyne B, laurefurenynes A/B and synthesis of an advanced intermediate reported in the earlier total synthesis of (<em>E</em>/<em>Z</em>)-elatenynes (formal Synthesis) are described. The salient features in the synthesis include epoxide opening, Birch reduction, Sharpless asymmetric dihydroxylation-cycloetherification, S<sub>N</sub>2 halogenation and a (relay-) cross-metathesis.
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Zenodo创建时间：
2021-05-03
