Chip-seq study for the genome-wide identification of CBX7 binding sites in CBX7 overexpressing CD34+ cellChip-seq study for genome-wide mapping of H3K9me3 and H3K27me3 in CD34+ cord blood cells upon overexpression of Polycomb CBX7 and Polycomb CBX8
收藏NIAID Data Ecosystem2026-03-10 收录
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Our study indicates that CBX7 regulates self-renewal of human HSC and is essential for leukemic cells suggesting that CBX7 qualifies as a new target protein in AML. CBX proteins have been described as readers of H3K27me3. Our identification of CBX7 binding H3K9 writers containing a trimethylated lysine suggests a novel role for CBX proteins, allowing crosstalks with other epigenetic repressing pathways.
创建时间：
2019-01-25
