RNA-seq analysis of archived blood and skin from common bottlenose dolphin (Tursiops truncatus) health assessments in the northern Gulf of Mexico, 2013-06-17 to 2018-07-20

Marine mammal health researchers use many standard veterinary panels, methods, and immune biomarkers, but there are likely additional biomarkers of health and toxicity that would further inform health assessments. Transcriptomic analysis is a powerful tool examining the molecular alterations that underlie toxic responses and disease and can yield extremely sensitive biomarkers. Archived blood (n = 76) and skin (n = 28) samples collected during common bottlenose dolphin health assessments in Barataria Bay, Louisiana and Sarasota, Florida from 2013-06-17 to 2018-07-20, were analyzed by RNA-seq to support and enhance the assessment of animal health. The raw sequence data and FPKM (fragments per kilobase of transcript per million mapped reads) values generated by sequence processing can be found by searching https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi for GSE138765 (blood) and GSE138935 (skin) or the individual accession numbers provided in the read me information.海洋哺乳动物健康研究人员已广泛采用多种标准兽医检测组合、实验方法及免疫生物标志物，但仍存在更多可用于完善健康评估的健康与毒性相关生物标志物有待发掘。转录组学分析是一项强大的研究工具，可解析毒性反应与疾病发生背后的分子改变，并可获得灵敏度极高的生物标志物。本研究针对2013年6月17日至2018年7月20日期间，在路易斯安那州巴拉塔里亚湾与佛罗里达州萨拉索塔开展的普通宽吻海豚健康评估中收集的存档样本进行了分析，其中血液样本76份、皮肤样本28份，采用RNA测序（RNA-seq）技术完成检测，以辅助并优化动物健康评估工作。经序列处理得到的原始测序数据及FPKM（fragments per kilobase of transcript per million mapped reads）数值，可通过在https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi 检索GSE138765（血液样本）与GSE138935（皮肤样本），或查阅自述文件中提供的单个登录号获取。