Psychosis Twins Study, Melbourne Neuropsychiatry Centre

This study aims to understand the role of genes in triggering the onset of a psychotic illness, and to identify biological and psychological markers of genetic risk for psychosis. Over 100 twin pairs with and without psychosis were recruited through clinical services and the Australian Twin Registry. These pairs have completed extensive brain imaging, neuropsychological and genetic assessments. Current analyses of these data are focusing on understanding how psychosis alters patterns of gene expression, and quantifying genetic influences on brain network organization. This project is being conducted in collaboration with The Queensland Centre for Mental Health Research. Recruitment for this study is now complete. MRI data is available for approximately 150 participants. Time Period: 1994-2008本研究旨在解析基因在触发精神病性疾病发病中的作用，并识别精神病性障碍遗传风险的生物学与心理学标志物。本研究通过临床医疗机构与澳大利亚双生子登记库（Australian Twin Registry）招募了超100对伴或不伴精神病性症状的双生子对，该队列已完成全面的脑成像、神经心理与遗传学评估。当前针对该数据集的分析工作聚焦于两大方向：一是解析精神病性症状如何改变基因表达模式，二是量化遗传因素对脑网络组织的影响。本项目与昆士兰心理健康研究中心（Queensland Centre for Mental Health Research）合作开展，受试者招募工作现已完成。 现有约150名受试者的磁共振成像（MRI）数据。 研究时段：1994年—2008年