Design, Synthesis, and Evaluation of the First Selective and Potent G-protein-Coupled Receptor Kinase 2 (GRK2) Inhibitor for the Potential Treatment of Heart Failure
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Design, Synthesis, and Evaluation of the First Selective and Potent G-protein-Coupled Receptor Kinase 2 (GRK2) Inhibitor for the Potential Treatment of Heart Failure Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3-({[4-methyl-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl]methyl}amino)-N-[2-(trifluoromethyl)benzyl]benzamide, Beta-adrenergic receptor kinase 1, ... Authors: Hoffman, I.D, Lawson, J.D. Deposit date: 2017-02-17 Release date: 2017-07-26 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Design, Synthesis, and Evaluation of the Highly Selective and Potent G-Protein-Coupled Receptor Kinase 2 (GRK2) Inhibitor for the Potential Treatment of Heart Failure. J. Med. Chem., 60, 2017
## 首个用于心力衰竭潜在治疗的选择性强效G蛋白偶联受体激酶2（G-protein-Coupled Receptor Kinase 2, GRK2）抑制剂的设计、合成与评价
数据集描述：2-(N-吗啉代)乙磺酸、3-({[4-甲基-5-(吡啶-4-基)-4H-1,2,4-三唑-3-基]甲基}氨基)-N-[2-(三氟甲基)苄基]苯甲酰胺、β肾上腺素能受体激酶1（Beta-adrenergic receptor kinase 1）等
作者：Hoffman, I.D、Lawson, J.D
存入日期：2017-02-17
发布日期：2017-07-26
最后修改日期：2024-03-06
测试方法：X射线衍射（分辨率2.7 Å）
引用文献：用于心力衰竭潜在治疗的高选择性强效G蛋白偶联受体激酶2（GRK2）抑制剂的设计、合成与评价. J. Med. Chem., 60, 2017
创建时间：
2017-02-17
