Rank of the “correct” motif in the output of various programs. “Target” refers to data sets defined in [3]. “Ref.” gives the accession number in the JASPAR or miRbase database, or the target consensus
We display the sensitivity (for specificity of 99%) on the independent test data set . Here we pick the optimal model from the cross validation experiment (green) and compare it with the PWM model (bl
BackgroundComputational de novo discovery of transcription factor binding sites is still a challenging problem. The growing number of sequenced genomes allows integrating orthology evidence with coreg
Critical developmental “master transcription factors” (MTFs) can be subverted during tumorigenesis to control expression of oncogenic transcriptional programs. Current approaches to identify MTFs rely
Non-coding genetic variants/mutations can play functional roles in the cell by disrupting regulatory interactions between transcription factors (TFs) and their genomic target sites. For most human TFs