Positive SNPs in PPARGC1B RUNX3 and TBKBP1 which are related to susceptibility to AS or severity of AS comparing all AS patients, severe AS patients and normal AS patients to the controls.

a“All” means the p value that we compare all the three genotype using 3×2 chi squared method. P-value for individual genotypes are shown only if significant at 0.05 level.bThe last lines of genotypes or alleles are the major genotypes or the major alleles. The other genotypes or alleles are compared to them. The relative risk associated with major genotypes and major alleles is estimated as an odds ratio (OR) with a 95% confidence interval (CI).cOR (95% CI) are adjusted by age and sex using multiple regression analysis.#indicates p-value is less than 0.05 but cannot pass Bonferroni correction which shows marginal significant difference.*indicates p-value is less than 0.01 which shows significant difference after Bonferroni correction. The details of all the 12 SNPs are summarized in Table S1 (PPARGC1B) Table S2 (RUNX3) and Table S3 (TBKBP1).