Structure of SARS-CoV-2 Main Protease bound to Tretazicar.
收藏Protein Data Bank Japan2025-10-01 更新2026-03-21 收录
下载链接：
https://pdbj.org/mine/summary/7ak4
下载链接
链接失效反馈官方服务：
资源简介：
Structure of SARS-CoV-2 Main Protease bound to Tretazicar. Descriptor: 3C-like proteinase, 5-(AZIRIDIN-1-YL)-2,4-DINITROBENZAMIDE, CHLORIDE ION, ... Authors: Guenther, S, Reinke, P, Oberthuer, D, Yefanov, O, Gelisio, L, Ginn, H, Lieske, J, Domaracky, M, Brehm, W, Rahmani Mashour, A, White, T.A, Knoska, J, Pena Esperanza, G, Koua, F, Tolstikova, A, Groessler, M, Fischer, P, Hennicke, V, Fleckenstein, H, Trost, F, Galchenkova, M, Gevorkov, Y, Li, C, Awel, S, Paulraj, L.X, Ullah, N, Falke, S, Alves Franca, B, Schwinzer, M, Brognaro, H, Werner, N, Perbandt, M, Tidow, H, Seychell, B, Beck, T, Meier, S, Doyle, J.J, Giseler, H, Melo, D, Dunkel, I, Lane, T.J, Peck, A, Saouane, S, Hakanpaeae, J, Meyer, J, Noei, H, Gribbon, P, Ellinger, B, Kuzikov, M, Wolf, M, Zhang, L, Ehrt, C, Pletzer-Zelgert, J, Wollenhaupt, J, Feiler, C, Weiss, M, Schulz, E.C, Mehrabi, P, Norton-Baker, B, Schmidt, C, Lorenzen, K, Schubert, R, Han, H, Chari, A, Fernandez Garcia, Y, Turk, D, Hilgenfeld, R, Rarey, M, Zaliani, A, Chapman, H.N, Pearson, A, Betzel, C, Meents, A. Deposit date: 2020-09-29 Release date: 2020-12-02 Last modified: 2025-10-01 Method: X-RAY DIFFRACTION (1.63 Å) Cite: X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease. Science, 372, 2021
与曲他卡（Tretazicar）结合的严重急性呼吸综合征冠状病毒2型（SARS-CoV-2）主蛋白酶结构。描述项：3C样蛋白酶（3C-like proteinase）、5-(1-氮丙啶基)-2,4-二硝基苯甲酰胺、氯离子…… 作者：Guenther, S、Reinke, P、Oberthuer, D、Yefanov, O、Gelisio, L、Ginn, H、Lieske, J、Domaracky, M、Brehm, W、Rahmani Mashour, A、White, T.A、Knoska, J、Pena Esperanza, G、Koua, F、Tolstikova, A、Groessler, M、Fischer, P、Hennicke, V、Fleckenstein, H、Trost, F、Galchenkova, M、Gevorkov, Y、Li, C、Awel, S、Paulraj, L.X、Ullah, N、Falke, S、Alves Franca, B、Schwinzer, M、Brognaro, H、Werner, N、Perbandt, M、Tidow, H、Seychell, B、Beck, T、Meier, S、Doyle, J.J、Giseler, H、Melo, D、Dunkel, I、Lane, T.J、Peck, A、Saouane, S、Hakanpaeae, J、Meyer, J、Noei, H、Gribbon, P、Ellinger, B、Kuzikov, M、Wolf, M、Zhang, L、Ehrt, C、Pletzer-Zelgert, J、Wollenhaupt, J、Feiler, C、Weiss, M、Schulz, E.C、Mehrabi, P、Norton-Baker, B、Schmidt, C、Lorenzen, K、Schubert, R、Han, H、Chari, A、Fernandez Garcia, Y、Turk, D、Hilgenfeld, R、Rarey, M、Zaliani, A、Chapman, H.N、Pearson, A、Betzel, C、Meents, A。存档日期：2020-09-29，发布日期：2020-12-02，最后更新：2025-10-01。实验方法：X射线衍射（分辨率1.63埃）。引用文献：《X射线筛选鉴定新型冠状病毒主蛋白酶的活性位点与变构抑制剂》，《科学》（Science），372卷，2021年
创建时间：
2020-09-29
