Matrix-Bound Growth Factors are Released upon Cartilage Compression by an Aggrecan-Dependent Sodium Flux that is Lost in Osteoarthritis (Proteomics)

Articular cartilage exhibits regional and depth-dependent biomechanical differences, which influence the transduction of load to chondrocytes and throughout the tissue matrix. One such mechanism is the biophysical release of proteins from the matrix. This study conducted proteomic analysis of rested porcine articular cartilage to assess regional protein abundance throughout distinct depths of porcine knee articular cartilage.