The PRAK-NRF2 axis promotes the differentiation of Th17 cells by mediating the redox homeostasis and glycolysis

To investigate the function of PRAK in the regulation of Th17 differentiation, we polarized wild type and PRAK-KO naïve CD4+ T cells into Th17 cells for 72h in vitro. We then collected two types of polarized Th17 cells and performed gene expression profiling analysis using data obtained from RNA-seq. Comparative gene expression profiling analysis of RNA-seq data for wild type and PRAK knock out Th17 cells.