Supplementary Tables 1 - 3 from Long-Range Chromatin Interactions Drive Mutant TERT Promoter Activation

Supplementary Table 1. Differential gene expression data list of BLM6 and BLM14 cells (-146C>T vs. -146C) for the genes that were predicted to be off-targets of the guide RNA that has been used for the CRISPR/Cas9 genome engineering. Supplementary Table 2. Table showing list of interacting regions obtained from 4C analysis. 4C was performed in BLM6 and BLM14 cells. Differential interactions were obtained from 4C analysis. List shows the genomic coordinates (column 1-3) and their Refseq identities (column 4) of regions interacting with mutant Tert promoter. Column 5 shows whether the regions were tested by 3C-qPCR assay. Y = Yes, N=No. Column 6 shows whether the region was removed by CRISPR/Cas9 editing in the later part of the study. * mark is named as T-INT1 region. Supplementary Table 3. Primer sequences for ChIP-qPCR, 4C and 3C and RT-qPCR experiments.

补充表1：BLM6和BLM14细胞中预测为CRISPR/Cas9基因组编辑所使用引导RNA的脱靶基因的差异表达数据列表（-146C>T vs. -146C）。补充表2：展示通过4C分析获得的相互作用区域列表。4C分析在BLM6和BLM14细胞中进行。4C分析获得了差异相互作用。列表展示了相互作用的区域基因组坐标（第1-3列）及其Refseq身份（第4列）。第5列显示该区域是否经过3C-qPCR检测。Y代表是，N代表否。第6列显示该区域是否在研究后期通过CRISPR/Cas9编辑被移除。*标记的T-INT1区域。补充表3：ChIP-qPCR、4C、3C和RT-qPCR实验的引物序列。