Regnase-1 suppresses TCF-1+ precursor exhausted T cell formation to limit CAR T cell responses against ALL [Microarray Expression]

transcriptional profiling was performed on WT and KO CAR T cells isolated 7 days after co-transfer into mice with or without tumors. Regnase-1 KO CAR T cells undergoing a tumor-dependent shift from an effector to memory-like phenotype In total 19 samples were analyzed: (WT CAR with tumor n=5; WT CAR without tumor n=4; KO CAR with tumor n=5, KO CAR without tumor n=5)