BindingDB Entry 50034359: Design, synthesis and antitumor activity of 4-aminoquinazoline derivatives targeting VEGFR-2 tyrosine kinase.

Small molecule binding data for protein Cyclin-dependent kinase 1, Epidermal growth factor receptor, Epidermal growth factor receptor and ErbB2 (HER1 and HER2), Fibroblast growth factor receptor 1, Focal adhesion kinase 1/vascular endothelial growth factor receptor 3, Platelet-derived growth factor receptor, Platelet-derived growth factor receptor beta, Serine/threonine-protein kinase Aurora, Vascular endothelial growth factor receptor, Vascular endothelial growth factor receptor 2, and Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2), Uniprot L7RSL3, O14965, P00533, P04626, P06493, P09619, P11362, P16234, P17948, P35916, P35968, and Q02763本数据集包含针对以下蛋白质的小分子结合数据：细胞周期蛋白依赖性激酶1（Cyclin-dependent kinase 1）、表皮生长因子受体（Epidermal growth factor receptor）、表皮生长因子受体与ErbB2（HER1及HER2）、成纤维细胞生长因子受体1（Fibroblast growth factor receptor 1）、黏着斑激酶1/血管内皮生长因子受体3（Focal adhesion kinase 1/vascular endothelial growth factor receptor 3）、血小板衍生生长因子受体（Platelet-derived growth factor receptor）、血小板衍生生长因子受体β（Platelet-derived growth factor receptor beta）、丝氨酸/苏氨酸蛋白激酶Aurora（Serine/threonine-protein kinase Aurora）、血管内皮生长因子受体（Vascular endothelial growth factor receptor）、血管内皮生长因子受体2（Vascular endothelial growth factor receptor 2），以及血管内皮生长因子受体2与酪氨酸蛋白激酶TIE-2（KDR及TIE2）；对应通用蛋白数据库（Uniprot）编号为L7RSL3、O14965、P00533、P04626、P06493、P09619、P11362、P16234、P17948、P35916、P35968及Q02763