Novel Amino-pyrazole Ureas with Potent In Vitro and In Vivo Antileishmanial Activity

Visceral leishmaniasis is a severe
parasitic disease that is one
of the most neglected tropical diseases. Treatment options are limited,
and there is an urgent need for new therapeutic agents. Following
an HTS campaign and hit optimization, a novel series of amino-pyrazole
ureas has been identified with potent in vitro antileishmanial activity.
Furthermore, compound 26 shows high levels of in vivo
efficacy (>90%) against Leishmania infantum, thus demonstrating proof of concept for this series.