Group deposition for crystallographic fragment screening of Coxsackievirus A16 (G-10) 2A protease -- Crystal structure of Coxsackievirus A16 (G-10) 2A protease in complex with Z50145861 (A71EV2A-x0341)

Group deposition for crystallographic fragment screening of Coxsackievirus A16 (G-10) 2A protease -- Crystal structure of Coxsackievirus A16 (G-10) 2A protease in complex with Z50145861 (A71EV2A-x0341) Descriptor: 5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one, DIMETHYL SULFOXIDE, Protease 2A, ... Authors: Lithgo, R.M, Fairhead, M, Koekemoer, L, Balcomb, B.H, Capkin, E, Chandran, A.V, Golding, M, Godoy, A.S, Aschenbrenner, J.C, Marples, P.G, Ni, X, Thompson, W, Tomlinson, C.W.E, Wild, C, Winokan, M, Xavier, M.-A.E, Fearon, D, von Delft, F. Deposit date: 2024-04-04 Release date: 2024-04-24 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (1.25 Å) Cite: Crystallographic Fragment Screen of Coxsackievirus A16 2A Protease identifies new opportunities for the development of broad-spectrum anti-enterovirals. Biorxiv, 2024

集体提交的柯萨奇病毒A16（Coxsackievirus A16，G-10株）2A蛋白酶晶体学片段筛选数据集——结合配体Z50145861（A71EV2A-x0341）的柯萨奇病毒A16（Coxsackievirus A16，G-10株）2A蛋白酶晶体结构 描述项：5-甲基-2-苯基-2,4-二氢-3H-吡唑-3-酮、二甲基亚砜（DIMETHYL SULFOXIDE）、2A蛋白酶（Protease 2A）等 作者：Lithgo, R.M.、Fairhead, M.、Koekemoer, L.、Balcomb, B.H.、Capkin, E.、Chandran, A.V.、Golding, M.、Godoy, A.S.、Aschenbrenner, J.C.、Marples, P.G.、Ni, X.、Thompson, W.、Tomlinson, C.W.E.、Wild, C.、Winokan, M.、Xavier, M.-A.E.、Fearon, D.、von Delft, F. 提交日期：2024-04-04 发布日期：2024-04-24 最后修改日期：2024-10-16 实验方法：X射线衍射法（X-RAY DIFFRACTION，分辨率1.25 Å） 引用文献：《柯萨奇病毒A16 2A蛋白酶的晶体学片段筛选发现广谱抗肠病毒药物开发新机遇》，BioRxiv，2024