Rates of myocardial infarction in men under and 65 and those 65 and older per 1,000(PY) in pre- and post-prescription intervals for an initial prescription for TT or PDE5 inhibitors, with adjusted^* rate ratios (RR), ratio of rate ratios (RRR) and 95% confidence limits (CL) by history of heart disease.

*Adjusted for age and pre-existing medical conditions and medication use associated with MI or its risk factors. †Effective sample size of PDE5 inhibitor cohort after weighting. Under 65 with heart disease history: 9,003. Under 65 without a history of heart disease: 112,588. 65 and older with heart disease history: 4,190. 65 and older without a history of heart disease: 15,718. ‡RRR = RR TT cohort/RR PDE5I cohort.