Efficacy of Ganciclovir Combined With Recombinant Human Interferon α-1b for Viral Encephalitis in Children

ObjectiveTo explore the efficacy of ganciclovir combined with recombinant human interferon α-1b in the treatment of viral encephalitis in children. Methods160 children with viral encephalitis admitted to third department of pediatrics of Xingtai People' s Hospital were selected, and divided into single group and combined group by random number table method, with 80 cases in each group. The single group was treated with ganciclovir, whereas the combined group was given ganciclovir combined with recombinant human interferon α-1b. Compare the time to recovery of symptoms in patients between groups. After 2 weeks of treatment, compare the clinical efficacy and EEG abnormalities between the two groups. The cerebral hemodynamics (mean blood flow velocity [Vm] and pulsatility index [PI] of anterior cerebral artery and posterior cerebral artery), neurological function (neuron specific enolase [NSE], neurotrophin3 [NT-3], nerve growth factor [NGF]), immune function (immunoglobulin A [IgA], IgG, IgE) and inflammatory factors (tumor necrosis factor α [TNF-α], interleukin β [IL-1β], interleukin 2 [IL-2]) before treatment and after 2 weeks of treatment were compared between groups, and the adverse reactions during treatment were recorded.ResultsThe disappearance durations of fever, headache, vomiting, convulsion, disturbance of consciousness and meningeal irritation in combined group were shorter than those in single group (P P P P > 0.05). The Vm and PI of anterior cerebral artery and posterior cerebral artery and levels of NSE, NGF, IgA, TNF-α, IL-1β and IL-2 were decreased in both groups, and the indicators in combined group were lower compared to single group (all P P P > 0.05). ConclusionGanciclovir combined with recombinant human interferon α-1b can effectively treat viral encephalitis in children, improve cerebral hemodynamics and neurological function, enhance immune function, and relieve inflammatory response, and it dose not increase adverse reactions.