Crystal structure of human CDK2 complexed with a pyrazolo[1,5-a]pyrimidine inhibitor

Crystal structure of human CDK2 complexed with a pyrazolo[1,5-a]pyrimidine inhibitor Descriptor: 4-[5-(TRANS-4-AMINOCYCLOHEXYLAMINO)-3-ISOPROPYLPYRAZOLO[1,5-A]PYRIMIDIN-7-YLAMINO]-N,N-DIMETHYLBENZENESULFONAMIDE, Cell division protein kinase 2 Authors: Williamson, D.S, Parratt, M.J, Torrance, C.J, Bower, J.F, Moore, J.D, Richardson, C.M, Dokurno, P, Cansfield, A.D, Francis, G.L, Hebdon, R.J, Howes, R, Jackson, P.S, Lockie, A.M, Murray, J.B, Nunns, C.L, Powles, J, Robertson, A, Surgenor, A.E. Deposit date: 2004-12-14 Release date: 2005-02-08 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Structure-guided design of pyrazolo[1,5-a]pyrimidines as inhibitors of human cyclin-dependent kinase 2. Bioorg.Med.Chem.Lett., 15, 2005

人源细胞周期蛋白依赖性激酶2（CDK2）与吡唑并[1,5-a]嘧啶（pyrazolo[1,5-a]pyrimidine）类抑制剂共晶结构。描述项：4-[5-(反式-4-氨基环己基氨基)-3-异丙基吡唑并[1,5-a]嘧啶-7-基氨基]-N,N-二甲基苯磺酰胺，细胞分裂蛋白激酶2。作者：Williamson, D.S.、Parratt, M.J.、Torrance, C.J.、Bower, J.F.、Moore, J.D.、Richardson, C.M.、Dokurno, P.、Cansfield, A.D.、Francis, G.L.、Hebdon, R.J.、Howes, R.、Jackson, P.S.、Lockie, A.M.、Murray, J.B.、Nunns, C.L.、Powles, J.、Robertson, A.、Surgenor, A.E.。提交日期：2004-12-14；发布日期：2005-02-08；最后更新日期：2023-08-23。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.15埃（Å）。引用文献：《结构导向设计吡唑并[1,5-a]嘧啶类化合物作为人源细胞周期蛋白依赖性激酶2抑制剂》，《Bioorg.Med.Chem.Lett.》，第15卷，2005年。