Dissection of multiple sclerosis genetics identifies B and CD4+ T cells as driver cell subsets

We have performed ATAC-seq from FACS sorted immune cell populations from peripheral blood of human donors. All donors have a diagnosis of multiple sclerosis and some donors were treated with immunotherapy (glatiramer acetate, interferon beta, or natalizumab). We called peaks from the ATAC-seq data and tested for enrichment of open chromatin regions for each cell population in MS GWAS. We examined open chromatin regions in FACS-sorted immune cell populations from peripheral blood of human donors with a diagnosis of multiple sclerosis