PLINK breed data showing SLAMF1 is associated with canine atopic dermatitis

Canine atopic dermatitis (CAD) is a common inflammatory skin condition in dogs. It is a life-long problem which poses a significant welfare issue due to the chronic skin discomfort and pruritus (itch) experienced. Excessive scratching, licking and chewing cause self-trauma to the skin and increased risk of secondary infections. Several breeds are predisposed including the Labrador Retriever, Boxer and French Bulldog, suggesting a genetic component to the condition. Our access to a sizeable population of dogs genotyped on a medium density single-nucleotide polymorphism (SNP) array along with linked clinical record information allows for large-scale and highly powered genome-wide association study (GWAS) analysis. In this study, over 28 thousand dogs were used to look for genetic changes associated with CAD. We identified a statistically significant signal on canine chromosome 38, with a particularly strong association in the French Bulldog breed. Genome resequencing revealed a provocativ..., Samples
DNA samples were collected via commercial testing of Wisdom Panel™ Premium, Wisdom Panel™ Essential, Wisdom Panel™ Health and Optimal Selection™ retail products, and genetic testing performed as a part of Optimal Wellness Plans® for puppies, through Banfield Pet Hospital branches (Vancouver, WA, USA) and as part of the MARS PETCARE BIOBANK™. Samples were either collected through non-invasive cheek swabbing by dog owners or veterinary professionals or through blood sampling by a veterinary professional at a Banfield Pet Hospital in line with regulations governing diagnostic testing. Consent for use of DNA data in research was obtained through the client’s agreement with terms and conditions of DNA testing through Wisdom Panel. Analysis and sequencing of cDNA were performed using samples collected from dogs participating in the Mars Petcare Biobank. All samples originated from the United States or Mexico. 
Analysis
An initial GWAS was performed using 14,378 single breed cases..., , # PLINK breed data showing SLAMF1 is associated with canine atopic dermatitis

[https://doi.org/10.5061/dryad.np5hqc053](https://doi.org/10.5061/dryad.np5hqc053)

## Description of the data and file structure

### Corresponding Author Contact Information

```
Name: Oliver P Forman
Institution: Wisdom Panel, Science and Diagnostics, Mars Petcare, US
Email: [e-mail]
```

### Dataset Overview

This dataset contains the Plink data required to replicate GWAS analysis in \"A splice donor variant in *SLAMF1* is associated with canine atopic dermatitis\", Oliver P. Forman, et al.

### Description of the data and file structure

Each of the datasets contains a set of binary Plink files (.bed, .bim and .bam) annotated with breed abbreviations and case and control numbers.

### Software

All available data was produced and can be manipulated with the free software [Plink v1.9](https://www.cog-genomics.org/plink/)

Files with the extensions bim and fam are plain text and viewable with...,