Irisin ameliorates the progression of intervertebral disc degeneration via LATS/YAP/CTGF signaling.

Taken together, this study demonstrated that FNDC5 was lost in degenerative NP tissues, while irisin treatment ameliorated the ECM metabolism of NPCs and delay the progression of IDD via LATS/YAP/CTGF signaling. Taken together, this study demonstrated that FNDC5 was lost in degenerative NP tissues, while irisin treatment ameliorated the ECM metabolism of NPCs and delay the progression of IDD via LATS/YAP/CTGF signaling. Overall design: Genome-wide transcriptional sequencing was applied between TNF-a treated groups and TNF-a with irisin treated groups to identify the differential expression levels of RNA.