Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues

Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 9H-purine-6,8-diamine, BAG FAMILY MOLECULAR CHAPERONE REGULATOR 1, ... Authors: Jones, A.M, Westwood, I.M, Osborne, J.D, Matthews, T.P, Cheeseman, M.D, Rowlands, M.G, Jeganathan, F, Burke, R, Lee, D, Kadi, N, Liu, M, Richards, M, McAndrew, C, Yahya, N, Dobson, S.E, Jones, K, Workman, P, Collins, I, van Montfort, R.L.M. Deposit date: 2015-09-22 Release date: 2016-10-05 Last modified: 2024-10-09 Method: X-RAY DIFFRACTION (1.96 Å) Cite: A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms. Sci Rep, 6, 2016

基于片段的热休克蛋白70（HSP70）筛选揭示三磷酸腺苷（ATP）结合位点残基的功能作用
描述符：2-氨基-2-羟甲基丙烷-1,3-二醇、9H-嘌呤-6,8-二胺、BAG家族分子伴侣调节因子1……
作者：Jones, A.M、Westwood, I.M、Osborne, J.D、Matthews, T.P、Cheeseman, M.D、Rowlands, M.G、Jeganathan, F、Burke, R、Lee, D、Kadi, N、Liu, M、Richards, M、McAndrew, C、Yahya, N、Dobson, S.E、Jones, K、Workman, P、Collins, I、van Montfort, R.L.M.
提交日期：2015-09-22
发布日期：2016-10-05
最后修改时间：2024-10-09
实验方法：X射线衍射（X-RAY DIFFRACTION，分辨率1.96埃）
引用文献：《针对高度柔性靶点的基于片段筛选方法：HSP70亚型抑制的研究洞察与挑战》，发表于《科学报告（Sci Rep）》，2016年，第6卷。