Carotid plaques - 3 years analysis

Indentify the factoprs influencing the carotid plaque progresssion. All consecutive patients from the ANTIQUE study (Atherosclerotic Plaque Characteristics Associated with a Progression Rate of the Plaque and a Risk of Stroke in Patients with the Carotid Bifurcation Plaque Study – ClinicalTrials.gov Identifier: NCT02360137) who underwent all clinical and ultrasound examinations over a 36-month period were included in the analysis. The ANTIQUE study inclusion criteria were as follows: patient age 30–90 years; atherosclerotic plaque localized in the carotid bifurcation or proximal part of the internal carotid artery with a width of ≥2.0 mm in B-mode transverse plane; sufficient image quality of atherosclerotic plaque in the carotid bifurcation and internal carotid artery (ICA) using ultrasound; self-sufficiency defined as a modified Rankin Scale score of 0–2 points; and signed informed consent was provided. Exclusion criteria were serious disease with a low probability of survival for at least three years and other objective obstacles preventing regular six-month ultrasound scans. Clinical examination All patients underwent neurological and physical examinations at six-month intervals over the course of 36 months. The examinations included blood pressure (one measurement at rest after the sonographic examination), height, and weight measurements (including calculation of body mass index), collection of demographic and medical data (age, gender, and medical history), occurrence of diseases (arterial hypertension, diabetes mellitus, hyperlipidemia, coronary heart disease, atrial fibrillation, myocardial infarction, or other cardiac diseases; stroke, including stroke type; and surgery or stenting of any vessels, including carotid arteries, coronary, or lower limb and other arteries), smoking, daily alcohol consumption dose, and medication use. Treatment All patients were treated using the “treating arteries instead of risk factors” strategy.

本研究旨在明确影响颈动脉斑块进展的相关因素。本分析纳入ANTIQUE研究（全称：颈动脉分叉斑块患者动脉粥样硬化斑块特征与斑块进展速率及卒中（stroke）风险关联研究——ClinicalTrials.gov注册号：NCT02360137）中，于36个月随访周期内完成全部临床检查与超声检查的所有连续性受试者。该研究的纳入标准如下：受试者年龄为30~90岁；动脉粥样硬化斑块局限于颈动脉分叉或颈内动脉（internal carotid artery, ICA）近端，B型超声横切面测量宽度≥2.0mm；超声下颈动脉分叉及颈内动脉的动脉粥样硬化斑块图像质量良好；改良Rankin量表（modified Rankin Scale）评分0~2分，提示生活自理；签署知情同意书。排除标准为：预计生存期不足3年的严重疾病患者，以及存在其他无法定期接受6个月一次超声检查的客观障碍者。临床检查：所有受试者在36个月随访周期内每6个月接受一次神经科及体格检查。检查内容包括：血压（超声检查后静息状态下测量1次）、身高与体重（用于计算体质量指数（body mass index, BMI））、人口统计学与医学资料（年龄、性别与病史）、疾病发生情况（动脉高血压（arterial hypertension）、糖尿病（diabetes mellitus）、高脂血症（hyperlipidemia）、冠心病（coronary heart disease）、心房颤动（atrial fibrillation）、心肌梗死（myocardial infarction）或其他心脏疾病；卒中，含卒中类型；以及任意血管包括颈动脉、冠状动脉、下肢动脉及其他动脉的手术或支架置入术（stenting）史）、吸烟情况、每日酒精摄入量与用药情况。治疗方案：所有受试者均采用“治疗动脉而非仅控制危险因素”的诊疗策略。

搜集汇总

背景与挑战

背景概述

该数据集旨在识别影响颈动脉斑块进展的因素，基于一项为期36个月的纵向研究（ANTIQUE研究），包含连续患者的临床和超声检查数据。数据集涵盖了患者人口统计学、病史、生活方式及斑块形态学测量，采用“治疗动脉而非风险因素”策略，适用于动脉粥样硬化风险因素相关医学研究。