Supplementary data 4. The interaction partners of the NAFLD-candidate genes from the liver-specific PPIN, their pathway enrichment result and the trait enrichment results of the eQTLs regulating them

The proteins directly interacting with the proteins encoded by NAFLD-candidate genes were identified from the liver-specific protein-protein interaction network (PPIN). The interacting partners were significantly enriched within biological pathways related to cancers and NAFLD pathogenesis. The eQTLs regulating the interacting partners were enriched for GWAS traits including those that were previously linked to or multimorbid with NAFLD.

通过对NAFLD候选基因编码蛋白直接相互作用蛋白的鉴定，构建了肝脏特异性蛋白-蛋白相互作用网络（PPIN）。这些相互作用伙伴在涉及癌症和NAFLD发病机理的生物学通路中显著富集。调控这些相互作用伙伴的eQTLs在包括之前与NAFLD相关联或多病共存的全基因组关联研究（GWAS）特征中富集。