Expression data from Hdac1 and 2 knock out microglia in 5X familial Alzheimer's disease (FAD) background. Mus musculus

Epigenetic alterations has been implicated in the pathology of several neurodegenerative diseases. To investigate the role of microglial Hdac1 and 2 in the pathogenesis of Alzheimer's disease (AD), we created microglia specific compound Hdac1 and Hdac2 knock out mice in 5X FAD background. Genetic ablation of Hdac1 and 2 from microglia reduced amyloid plaque burden and improved spatial learning and memory function. To study how Hdac1 and 2 knock out in microglia alters gene expression profile in 5X FAD mice we carry out microarray analysis using 24-28 weeks animals Overall design: We used FACS sorted microglia cells from wild type (WT), FAD Hdac1/2fl/fl (FAD) and FAD Hdac1/2fl/flCx3cr1CreERT2 (FAD DKO) mice at 24-28 weeks of age