Crystal structure of broadly neutralizing antibody mAb1382 in complex with Hepatitis C virus envelope glycoprotein E2 ectodomain

Crystal structure of broadly neutralizing antibody mAb1382 in complex with Hepatitis C virus envelope glycoprotein E2 ectodomain Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Flyak, A.I, Bjorkman, P.J. Deposit date: 2021-07-14 Release date: 2022-01-12 Last modified: 2024-10-09 Method: X-RAY DIFFRACTION (3.24 Å) Cite: Analysis of antibodies from HCV elite neutralizers identifies genetic determinants of broad neutralization. Immunity, 55, 2022广谱中和抗体mAb1382与丙型肝炎病毒（Hepatitis C virus）包膜糖蛋白E2胞外域复合物的晶体结构 配体描述符：2-乙酰胺基-2-脱氧-β-D-吡喃葡萄糖（2-acetamido-2-deoxy-beta-D-glucopyranose）、2-乙酰胺基-2-脱氧-β-D-吡喃葡萄糖-(1-4)-2-乙酰胺基-2-脱氧-β-D-吡喃葡萄糖、α-D-吡喃甘露糖（alpha-D-mannopyranose）-(1-3)-[α-D-吡喃甘露糖（alpha-D-mannopyranose）-(1-6)]β-D-吡喃甘露糖-(1-4)-2-乙酰胺基-2-脱氧-β-D-吡喃葡萄糖-(1-4)-2-乙酰胺基-2-脱氧-β-D-吡喃葡萄糖，…… 作者：Flyak, A.I.、Bjorkman, P.J. 入库日期：2021-07-14 发布日期：2022-01-12 末次修改日期：2024-10-09 实验方法：X射线衍射（分辨率3.24 Å） 引用文献：《丙型肝炎病毒精英中和者体内抗体分析鉴定广谱中和的遗传决定因子》，《免疫（Immunity）》，第55卷，2022年