Group deposition for crystallographic fragment screening of Coxsackievirus A16 (G-10) 2A protease -- Crystal structure of Coxsackievirus A16 (G-10) 2A protease in complex with Z56042334 (A71EV2A-x1140)

Group deposition for crystallographic fragment screening of Coxsackievirus A16 (G-10) 2A protease -- Crystal structure of Coxsackievirus A16 (G-10) 2A protease in complex with Z56042334 (A71EV2A-x1140) Descriptor: 1-(2-chlorophenyl)-2-(pyrrolidin-1-yl)ethan-1-one, DIMETHYL SULFOXIDE, Protease 2A, ... Authors: Lithgo, R.M, Fairhead, M, Koekemoer, L, Balcomb, B.H, Capkin, E, Chandran, A.V, Golding, M, Godoy, A.S, Aschenbrenner, J.C, Marples, P.G, Ni, X, Thompson, W, Tomlinson, C.W.E, Wild, C, Winokan, M, Xavier, M.-A.E, Fearon, D, von Delft, F. Deposit date: 2024-04-04 Release date: 2024-04-24 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (1.52 Å) Cite: Crystallographic Fragment Screen of Coxsackievirus A16 2A Protease identifies new opportunities for the development of broad-spectrum anti-enterovirals. Biorxiv, 2024

柯萨奇病毒A16（Coxsackievirus A16）毒株G-10的2A蛋白酶（Protease 2A）晶体学片段筛选群组沉积数据 —— 结合配体Z56042334（A71EV2A-x1140）的柯萨奇病毒A16毒株G-10 2A蛋白酶晶体结构
描述符：1-(2-氯苯基)-2-(吡咯烷-1-基)乙-1-酮、二甲基亚砜（DIMETHYL SULFOXIDE）、2A蛋白酶等
作者：Lithgo, R.M、Fairhead, M、Koekemoer, L、Balcomb, B.H、Capkin, E、Chandran, A.V、Golding, M、Godoy, A.S、Aschenbrenner, J.C、Marples, P.G、Ni, X、Thompson, W、Tomlinson, C.W.E、Wild, C、Winokan, M、Xavier, M.-A.E、Fearon, D、von Delft, F
沉积日期：2024-04-04
发布日期：2024-04-24
最后修改日期：2024-10-16
实验方法：X射线衍射（X-RAY DIFFRACTION，分辨率1.52 Å）
引用文献：《柯萨奇病毒A16型毒株G-10 2A蛋白酶的晶体学片段筛选发现广谱抗肠病毒药物开发新机遇》，BioRxiv，2024