File S1 - Dynamical Modeling of the Cell Cycle and Cell Fate Emergence in Caulobacter crescentus

Sheet 1: Complete network G1 with the complete list of genes/proteins in associated to the cell cycle control in C. crescestus; the biological function, type of interaction and kind of regulation are described for each node, including the PubMed ID (PMID) of their experimental evidence. Sheet 2: List of genes/proteins in the reduced network G2. The biological function, type of interaction and the kind of regulation are described for each node, including the PubMed ID (PMID) of their experimental evidence. Sheet 3: Logical functions and their rules as well as their respective biological descriptions. Sheet 4: Simulation of the network dynamics. Table S1: Complete network (G1) of regulators and their interactions associated to the control of the cell cycle in C. crescentus. Table S2: Reduced network (G2) of proteins and their interactions for the cell cycle control in C crescentus. Table S3: Logical function for the expression or inhibition of CtrA. Table S4: Logical function for the expression or inhibition of GcrA. Table S5: Logical function for the expression or inhibition of DnaA. Table S6: Logical function for the expression or inhibition of CcrM. Table S7: Logical function for the expression or inhibition of SciP. Table S8: Logical function for the phosphorylation or degradation of CtrA. Table S9: Logical function for the phosphorylation or dephosphorylation of DivK. Table S10: Logical function for the phosphorylation or dephosphorylation of PleC. Table S11: Logical function for the phosphorylation or dephosphorylation of DivJ. Table S12: Logical function for the activation of DivL. Table S13: Logical function describing the activation of inhibition of CckA. Table S14: Logical function for the phosphorylation or dephosphorylation of ChpT. Table S15: Logical function for the phosphorylation or dephosphorylation of CpdR. Table S16: Logical function for the assembly or unassembly of the ClpXP-RcdA complex. Table S17: Cyclic states for regulators of the cell cycle network. Table S18: Punctual attractor states in the dynamics of the phospho-proteolytic network. Table S19: Steady states after deleting genes ctrA, gcrA, dnaA, ccrM, and sciP (one at a time) in the cell cycle network G2a. Table S20: Steady states after fixing the values of CtrA, GcrA, DnaA, CcrM, and Scip in the cell cycle network G2a. Table S21: Steady states after deleting genes ctrA, divK, pleC, divJ, divL, cckA, chpT, cpdR and the complex clpXP-rcdA in the phospho-proteolytic network G2b. Table S22: Steady states after fixing the values of CtrA, DivK, PleC, DivJ, DivL, CckA, ChpT, CpdR, and ClpXP-RcdA in the phospho-proteolytic network G2b. (XLSX)