iPSCORE Multiomic QTL Summary Statistics

This directory contains 16 summary statistics files from quantitative trait loci (QTL) analyses for three molecular phenotypes (gene expression [eQTLs], chromatin accessibility [caQTLs], and H3K27ac acetylation [haQTLs]) were identified in three tissues from the iPSCORE Collection; induced pluripotent stem cells (iPSCs), iPSC-derived cardiovascular progenitor cells (CVPCs), and iPSC-derived pancreatic progenitor cells (PPCs).Between the three tissues, we calculated QTLs in 8 molecular datasets in the "discovery" phase. After the discovery phase, we identified and processed significant QTLs for "downstream" analyses. Please see the Methods of the linked publication for details about the filtering and processing strategy. Each dataset has a summary statistics for the "discovery" and "downstream" stages of the analyses.

本目录包含来自 iPSCORE 收集的三个分子表型（基因表达 [eQTLs]、染色质可及性 [caQTLs] 和 H3K27ac 乙酰化 [haQTLs]）在三个组织（诱导多能干细胞 [iPSCs]、iPSC 衍生的心血管祖细胞 [CVPCs] 和 iPSC 衍生的胰腺祖细胞 [PPCs]）中的 16 个定量性状位点（QTL）分析的汇总统计文件；在三个组织之间，我们计算了 8 个分子数据集在“发现”阶段的 QTLs。在发现阶段之后，我们识别并处理了用于“下游”分析的显著 QTLs。有关筛选和处理策略的详细信息，请参阅相关联出版物的方法部分。每个数据集均包含分析“发现”和“下游”阶段的汇总统计信息。