The Synthesis of Multisubstituted Pyrroles via a Copper-Catalyzed Tandem Three-Component Reaction

An
unprecedented nucleophilic addition/cyclization/aromatization
cascade of basic chemicals, i.e., aromatic alkenes/alkynes, trimethylsilyl
cyanide and N,N-disubstituted formamide,
has been developed to give a series of multisubstituted pyrroles in
moderate to good yields with high regioselectivities. This reaction
not only reveals a new reaction mode for α-aminonitriles, but
also provides a new and efficient cyclization pattern for the synthesis
of multisubstituted pyrroles as well as their derivatives, which might
facilitate related biological studies.