miR-20a regulates fatty acid metabolism in metabolic CRC

Single-driver molecular events specific to the metabolic colorectal cancer (CRC) have not been clearly elucidated. Herein, we identified 12 functional miRNAs linked to activated metabolism by integrating multi-omics features in metabolic CRC. These miRNAs exhibited significantly enriched CRC driver miRNAs, significant impacts on CRC cell growth and significantly correlated metabolites.与代谢型结直肠癌（CRC）特异性相关的单驱动分子事件尚未得到清晰阐明。本研究通过整合代谢型结直肠癌的多组学特征，筛选出12个与代谢激活相关的功能性微小RNA（microRNA，miRNA）。这些miRNAs展现出显著的结直肠癌驱动miRNA富集特征，对结直肠癌细胞生长具有显著影响，且与相关代谢物存在显著相关性。