Profiling of N6-methyladenosine in mouse embryonic stem cells: Setd2 knockdown and control cells
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https://www.ncbi.nlm.nih.gov/sra/SRP132571
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资源简介：
Setd2 is the specific methyltransferase of H3K36me3. To understand the global effect of H3K36me3 on m6A modification, we used mouse embryonic stem cells (mESCs) model with doxycycline (Dox)-induced Setd2 knockdown, and performed m6A-IP followed by sequencing in mESCs with or without Dox treatment. We found that depletion of H3K36me3 by Setd2 silencing globally reduced m6A in mouse transcriptome. Overall design: m6A-seq in mESCs with or without Dox-induced Setd2 knockdown.
创建时间：
2019-09-23
