miRNA sequencing of primary mouse dorsal root ganglia

Peripheral nerve regeneration after injury is a complex process involving a large number of transcriptional changes. How these changes impact the regenerative outcome is though, poorly understood. Here, we take advantage of the genetically based differences in the peripheral and central regenerative capacity of CAST/Ei and C57BL/6j inbred mice to better understand the molecular bases driving superior regeneration in the CAST/Ei mouse strain. 14 samples were analyzed with 3 to 5 biological replicates per sample type损伤后周围神经再生是一个涉及大量转录改变的复杂生物学过程。然而，此类转录改变如何影响再生结局，目前仍知之甚少。本研究借助CAST/Ei与C57BL/6j近交系小鼠在周围与中枢神经再生能力上的遗传差异，以解析驱动CAST/Ei品系小鼠实现更优再生的分子基础。本研究共分析14份样本，每类样本设置3至5次生物学重复。