Peripheral nervous system features in chemotherapy-induced neuropathy models

Chemotherapy-induced peripheral neurotoxicity (CIPN) crucially worse the prognosis of cancer patients, and no treatments are so far available. The treatment of several tumors becomes problematic or prohibitive in patients with severe CIPN, crucially worsening the prognosis. In murine models of CIPN, the Caudal and the Sciatic nerves (CN, SN) has been identified as two fundamental characters of the etiology. Here, we postulated that early angiogenetic mechanisms start in the peripheral nervous compartments (the dorsal root ganglion, DRG, the sciatic and caudal nerves, SN, CN) mainly affected by the chemotherapy neurotoxicity. However, subcellular structures of DRG, SN and CN are inaccessible by micrometer resolution imaging techniques and, thus, require a more detailed setups. A unprecedented investigation with nanotomography of these tissues is proposed.