In-situ microtomography study of bio-regenerated human bone applying axial mechanical load

In oral implantology bone regenerative procedures are frequently required before implants can be placed. In this context, sinus floor augmentation (SFA) procedures have become a well-established pre-implantology procedure. To avoid harvesting autogenous bone grafts, there has been an ever increasing quest for adequate bioactive bioceramic synthetic bone grafting materials, which enhance bone formation and degrade in timely fashion. In the context of our research program novel bioceramics based on a silica containing calcium alkali orthophosphate (Si-CAOP) were developed, displaying a better biodegradability than the clinically established tricalcium phosphates (TCP). To this end, and in order to shed light on the complex bioactive ceramic enhanced bio-regeneration of the bone tissue non-destructively in 3D, synchrotron microtomography (SµCT) is then used to study samples from theses biopsies of bioregenerated bone in the sinus floor 6 months after implantation.