Beta-Lactamase Alleles

The spread of beta-lactamases, which confer resistance to beta-lactam antibiotics, is a serious clinical and public health problem. Genotypic and functional characterization of beta-lactamases is critical. The curation of many of these medically-important enzymes has in the past been performed solely by Drs. Karen Bush, George Jacoby, and Timothy Palzkill and has been hosted at the Lahey Clinic. After discussion with the above experts and additional experts that initially convened at the ICAAC 2015 conference, NCBI is now hosting the data to ensure the long-term stability of this important resource. This project reflects gene transformed beta lactamases in a susceptible host.