TARGET-seq+ genotyping data

Genotyping data for TARGET-seq+ from bone marrow samples from 9 cases with clonal hematopoiesis and 1 control sample.For each mutation and each single cell, data are provided for the genomic DNA amplicon (".gDNA"), the mRNA/cDNA amplicon (".mRNA"; if present) and the heterozygous germline SNP ("SNP."; if present). Where multiple mutations were amplified in a single cell, data for these are shown in separate lines.Genotypes were called separately for the genomic DNA amplicon ("genotype.gDNA"), and the mRNA/cDNA amplicon ("genotype.mRNA"). Zygosity was called for heterozygous SNPs where these were present in the amplicon.The final column indicates the consensus cell genotype for that mutation, integrating information from gDNA, mRNA and heterozygous SNPs.Column descriptionsCell = Cell IDSample = Donor IDSample_type = Type of sample; CH = clonal haematopoiesis sample; WT_control = non-CH wild-type control sample; No_template_control = empty well controlPlate = Plate IDmutation = mutation amplifiedcoverage.gDNA = total coverage of locus in gDNA ampliconRef.gDNA = reference allele count in gDNA ampliconMut.gDNA = mutant allele count in gDNA ampliconVAF.gDNA = variant allele frequency in gDNA amplicongenotype.gDNA = genotype called in gDNA ampliconcoverage.mRNA = total coverage of locus in mRNA ampliconRef.mRNA = reference allele count in mRNA ampliconMut.mRNA = mutant allele count in mRNA ampliconVAF.mRNA = variant allele frequency in mRNA amplicongenotype.mRNA = genotype called in mRNA ampliconSNP = Name of the germline SNP (if present) found near the mutation locus, covered by the gDNA ampliconSNP.coverage = total coverage across the SNP in the gDNA ampliconSNP.ref = reference allele count for the SNPSNP.alt = alternate allele count for the SNPSNP.VAF = variant allele frequency for the SNP (alternate allele)SNP.genotype = genotype called for the SNP; Het = Heterozygous biallelic detection; Hom_Ref = homozygous reference; Hom_Alt = homozygous alternategenotype = consensus genotype