NOTCH1 gain-of-function mutations are recurrent in B cell chronic lymphocytic leukemia (B-CLL), where they are associated with accelerated disease progression and refractoriness to chemotherapy. The s

NIAID Data Ecosystem30

DataSheet_1_The DCMU Herbicide Shapes T-cell Functions By Modulating Micro-RNA Expression Profiles.pdf

环境化学物免疫毒性

miRNA免疫调控

DCMU [N-(3,4-dichlorophenyl)-N-dimethylurea] or diuron is a widely used herbicide, which can cause adverse effects on human, especially on immune cells, due to their intrinsic properties and wide dist

NIAID Data Ecosystem20

Homo sapiens

淋巴细胞白血病分子机制

microRNA靶基因

MicroRNAs are known to inhibit gene expression by binding to the 3Â´UTR of the target transcript. Downregulation of miR-223 has been recently reported to have prognostic significance in CLL. However,

NIAID Data Ecosystem30

Real-time quantitative PCR analysis of EV-associated miRNAs from Human Tconv cell

miRNA免疫调控

T细胞效应功能

MicroRNAs (miRNAs) are small non-coding molecules targeting messenger RNAs and inhibiting protein translation. Regulated by dynamic micro-environmental cues, miRNAs in turn modulate key biological pro

NIAID Data Ecosystem30

miRNA regulation by interleukin-4 (IL-4) in chronic lymphocytic leukemia (CLL)

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