Propranolol pharmacokinetic data.

Abbreviations: AUC = area under the concentration-time curve; Cl = clearance; Cmax = peak concentration, Cmin = trough concentration, F = oral bioavailability, T1/2 = elimination half-life; Tmax = time point of Cmax; Vd = volume of distribution, NA = not available. Data are summarised as mean ± standard error of the mean or median as appropriate. †Case excluded from AUC and Cl statistics due to the effect of concomitant treatment with ciprofloxacin (see main body of text for mechanistic explanation), *p<0.01 vs. control subjects, **p<0.05 vs. control subjects, ¥corrected for dose.