Ribociclib derivative Rib-CA suppresses breast cancer progression by inducing p53-dependent apoptosis

RNA sequencing and bioinformatics analysis revealed 2628 differentially expressed genes, with functional enrichment indicating strong associations with the p53 pathway, apoptosis, and G2/M checkpoint regulation Overall design: In order to investigate the role and mechanism of Rib_CA in Breast Cancer, we treated MDA-MB-231 cells with Rib_CA and without treatment. Then, we performed gene expression profiling analysis using RNA seq data from Rib_CA and DMSO cells.