The occurrence of mutations in the hypervariable region of the VH chain of the monoclonal antibodies when compared against their germline gene sequence and the observed R (Replacement) and S (Silent) mutations.
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Regions beyond FR3 are not considered for the analysis as they form the junction region and the origin of the junction regions cannot be predicted accurately [57] (FR = Framework Region, CDR = Complementarity Determining Regions).
创建时间：
2015-12-02
