RareLSD: a manually curated database of lysosomal enzymes associated with rare diseases

RareLSD: A Database of Lysosomal Enzymes Associated with Rare Diseases Welcome to the official repository and documentation overview for RareLSD, a manually curated database dedicated to lysosomal enzymes and their associated rare disorders. This platform integrates clinical, biochemical, and structural data to facilitate the study of lysosomal storage disorders (LSDs) and assist in the rational design of therapeutic interventions. Web Server: https://webs.iiitd.edu.in/raghava/rarelsd/ Git Hub: https://github.com/sudhanshus-hash/RareLSD Citation Akhter, S., Kaur, H., Agrawal, P., & Raghava, G. P. S. (2019). RareLSD: a manually curated database of lysosomal enzymes associated with rare diseases. Database, 2019, baz112. https://doi.org/10.1093/database/baz112 About the Database RareLSD was developed to address the lack of a centralized repository for the proteins involved in lysosomal storage defects. These rare monogenic disorders, caused by the malfunctioning of hydrolytic enzymes within the lysosome, lead to the toxic accumulation of undegraded substrates. RareLSD provides a one-stop compendium for researchers to understand these biocatalysts from a molecular and clinical perspective. The database integrates data from: Primary Literature: Information curated from over 1,500 research articles and patient case reports. External Repositories: Data integrated from OMIM, UniProt, GeneCards, MalaCards, and PubChem. Structural Data: Protein structures sourced from the PDB or predicted using Phyre2.