Carbofunctionalization of Terminal Alkynes via Rhodium Catalysis Enabling Formations of Four Different Bonds
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https://figshare.com/articles/dataset/Carbofunctionalization_of_Terminal_Alkynes_via_Rhodium_Catalysis_Enabling_Formations_of_Four_Different_Bonds/22285088
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资源简介：
Described here is the oxygenative
carbofunctionalization of terminal
alkynes mediated by combined rhodium catalysis that enables regioselective
quadruple formation of C–C, C–H, C–O, and C–heteroatom
bonds. Mechanistic studies suggest that a disubstituted rhodium vinylidene
complex is generated upon C–C bond formation at the terminal
alkyne with tethered electrophiles such as alkyl halides, aldehydes,
imines, and Michael acceptors. Subsequent intermolecular transfer
oxygenation of the rhodium vinylidene with pyridine N-oxide generates a rhodium-complexed ketene intermediate that reacts
with a variety of heteroatom nucleophiles to give rise to cyclic carboxylic
acid derivatives.
创建时间：
2023-03-16
