Early-Stage Mycosis Fungoides: Searching for biomarkers associated with advanced stage progression Item (Supplementary data)

This study shows that the microenvironment and probably the phenotype of neoplastic T-cells of early-stage MF samples from MF-patients who suffered progression or remained stable is different. Moreover, we propose that the overexpression of CD30, CXCL13 and BIRC3 in early-stage MF is related to progression. Further spatial transcriptomics studies and single cell analysis are needed to corroborate our findings, in addition to allowing a much more specific separation between the microenvironment of lesions and tumour cells.