官方服务：
资源简介：
HLX regulates myeloid differentiation
应用场景：
创建时间：
2018-02-08
相关数据集
The dose-dependent role of PU.1 in Myeloid differentiation [small RNA-Seq]
A doxycycline-inducible system was used to induce PU.1 expression in cultured myeloid cell lines. The parent cell line used was BN (Kamath et al., Leukemia 22:1214-1225, 2008). Induction of PU.1 expre
NIAID Data Ecosystem70
Extensive epigenetic priming in multipotent progenitors precedes lineage specification in B-lymphocyte development.
B-lymphocyte development is dependent on the interplay between the chromatin landscape and lineage specific transcription factors. It has been suggested that B-lineage commitment is associated with ma
NIAID Data Ecosystem50
An evolutionary recent IFN-IL-6-CEBP axis is linked to monocyte expansion and tuberculosis severity in humans.
Monocyte counts are increased during human tuberculosis (TB) but it has not been determined whether Mycobacterium tuberculosis (Mtb) directly regulates myeloid commitment. We demonstrated that exposur
NIAID Data Ecosystem50
Control of Ribosomal RNA Synthesis by Hematopoietic Transcription Factors
Detailed description of this data can be accessed in Antony et al titled "Control of Ribosomal RNA Synthesis by Hematopoietic Transcription Factors".
NIAID Data Ecosystem60
Genotoxic aldehyde stress prematurely ages hematopoietic stem cells in a p53-driven manner
Aged hematopoietic stem cells (HSC) display diminished self-renewal and a myeloid differentiation bias. However, the physiological drivers and molecular processes that underpin this fundamental switch
NIAID Data Ecosystem50
