Regulation of TLR8-activated gene expression in human neutrophils [ChIP-seq]
收藏NIAID Data Ecosystem2026-05-02 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE119392
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The transcription factors that regulate gene expression in stimulated neutrophils are poorly characterized. Herein, we found that the genomic distribution of the myeloid lineage determining transcription factors PU.1 and C/EBPβ, as well as that of the histone modification H3K27Ac, which marks active chromatin, significantly change in human neutrophils treated with R848, a ligand of TLR8. Examination of histone modification, transcription factor binding and transcriptome in human neutrophils and granulocytic-differentiated HL-60 cell line
创建时间：
2025-01-22
