Applications of Multicomponent Reactions for the Synthesis of Diverse Heterocyclic Scaffolds

A four-component coupling process involving sequential reactions of aldehydes, primary amines, acid chlorides, and nucleophiles has been
developed to prepare multifunctional substrates that may be employed in subsequent ring-forming reactions to generate a diverse array of
functionalized heterocyclic scaffolds. This new approach to diversity-oriented synthesis was then applied to the first total synthesis of the
isopavine alkaloid (±)-roelactamine.